Hydrochloric Acid → 6-Chloro1,3-dihydro-1'-methylspiro[isobenzofuran-1,4'-piperidine]

HRID 1657856Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]O)=[C:4]([C:10]2([OH:17])[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)[CH:3]=1.Cl>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5]([CH2:8][O:17][C:10]32[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]3)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 867335284-(4-Chloro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine

Product 1

HCID 215068256-Chloro1,3-dihydro-1'-methylspiro[isobenzofuran-1,4'-piperidine]

Procedure

Treatment of 4-(4-chloro-α-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine with hydrochloric acid by the method described in Example 16d provides 6-chloro-1,3-dihydro-1'-methylspiro[isobenzofuran-1,4'-piperidine].

Sources & evidence

ORD record: ord-56726de3b1d946928c6889960264b828
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03962259

Reaction notes

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