Methanol → HCID 15730688, compound

HRID 1657899Notes

Reaction equation

HRID 1657899 reaction equation
[I-].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]([C:14](=[CH2:20])[CH2:15][N+](C)(C)C)=[CH:9][CH2:8][CH2:7]2.[CH3:21][OH:22]>[Ag]=O.O>[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]([C:14]([CH2:15][C:13]1([CH3:12])[C:21](=[O:22])[CH2:6][CH2:5][C:4]1=[O:3])=[CH2:20])=[CH:9][CH2:8][CH2:7]2

Participants

5

Reactant 2

HCID 887MethanolHCID 68144145HCID 68144145, compound

Product 1

HCID 15730688HCID 15730688, compound

Reagents, catalysts & solvents 2

HCID 92152Silver(II) oxideCatalystHCID 962WaterSolvent

Procedure

To a solution containing 13.3 parts of 2-(6-methoxy-3,4-dihydro-1-naphthyl)-2-propen-1-yl trimethylammonium iodide in 200 parts by volume of methanol and 1 part by volume of water is added 4.1 parts of silver oxide and the resulting reaction mixture is stirred for approximately 2 hours. At the end of that time the mixture is filtered into a container holding 4 parts of 2-methylcyclopentane-1,3-dione. The resulting solution is concentrated to a small volume and 500 parts by volume of xylene, 5 parts by volume of hexamethylphosphoramide and 5 parts by volume of triethylamine are added. Approximately 50 parts by volume of solvent is removed by distillation and the resulting mixture is heated gently at the reflux temperature for about 20 hours, then allowed to cool. That solution is washed successively with water, 5% hydrochloric acid, water, 5% aqueous sodium bicarbonate and water again, after which time the mixture is dried over anhydrous sodium sulfate and concentrated to a small residue. Crystallization of that crude product from methanol affords 2-(6-methoxy-3,4-dihydro-1-naphthyl)-3-(2-methylcyclopentane-1,3-dione-2-yl)propene, melting at about 81°-82° and displaying an ultraviolet absorption at about 274 millimicrons with a molecular extinction coefficient of approximately 10,400.

Workup

  1. customthe resulting reaction mixture
  2. filtrationAt the end of that time the mixture is filtered into a container
  3. concentrationThe resulting solution is concentrated to a small volume and 500 parts by volume of xylene, 5 parts by volume of hexamethylphosphoramide and 5 parts by volume of triethylamine
  4. additionare added
  5. customApproximately 50 parts by volume of solvent is removed by distillation
  6. temperaturethe resulting mixture is heated gently at the reflux temperature for about 20 hours
  7. temperatureto cool
  8. washThat solution is washed successively with water, 5% hydrochloric acid, water, 5% aqueous sodium bicarbonate and water again
  9. dry with materialafter which time the mixture is dried over anhydrous sodium sulfate
  10. concentrationconcentrated to a small residue
  11. customCrystallization of that crude product from methanol

Sources & evidence

ORD record
ord-8d8ea4490daf4420a952228dde1437e4
Source dataset
uspto-grants-1976_06
Patent number
US03962291

Reaction notes

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