反应详情

100 g of 2-acetoxy-2-methylethane-phosphonic acid dimethyl ester are heated for about 5 hours to 65°-75°C in 200 ml of methanol containing 1 wt.% of HCl. A mixture of methyl acetate/methanol is removed continuously by distillation over a column. The residue is fractionated in high vacuum. 60 g of 2-hydroxy-2-methyl-ethane-phosphonic acid dimethyl ester (b.p.: 125°-127°C/1.5 torr) are obtained, corresponding to a yield of 76% of the theoretical.

1. customis removed continuously by distillation over a column