Hydrochloric Acid → HCID 21532402, compound

HRID 1657989Notes

Reaction equation

HRID 1657989 reaction equation
[CH2:1]([O:3][P:4]([CH2:9][CH2:10][O:11]C(=O)C)(=[S:8])[O:5][CH2:6][CH3:7])[CH3:2].Cl>CO>[CH2:1]([O:3][P:4]([CH2:9][CH2:10][OH:11])(=[S:8])[O:5][CH2:6][CH3:7])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21532400HCID 21532400, compound

Product 1

HCID 21532402HCID 21532402, compoundYield 95.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

149 g of 2-acetoxyethane-thiophosphonic acid-O,O-diethyl ester (preparation according to German Offenlegungsschrift No. 2.127.821) are heated to 65°-70°C in 100 ml of methanol containing 3 wt.% of HCl, while removing simultaneously by distillation a mixture of methyl acetate/methanol. The reaction is terminated after approx. 5 hours. The residue is submitted to distillation under reduced pressure; 117 g of 2-hydroxyethanethiophosphonic acid-O,O-diethyl ester (b.p. 84°-88°C/0.1 torr) are obtained, corresponding to a yield of 95% of the theoretical.

Workup

  1. customwhile removing simultaneously by distillation
  2. additiona mixture of methyl acetate/methanol
  3. customThe reaction is terminated after approx. 5 hours
  4. distillationThe residue is submitted to distillation under reduced pressure

Sources & evidence

ORD record
ord-27713f7210cd42efa3e22ec9df170756
Source dataset
uspto-grants-1976_06
Patent number
US03962378

Reaction notes

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