反应详情

A solution of 2-oxo-propyl N-(p-methoxybenzyloxycarbonyl-diethylphosphonomethyl)thioformimidate (59 mg.) in acetone (0.5 ml.) is stirred with powdered potassium carbonate (25 mg.) for 21 hours at room temperature and under a nitrogen atmosphere. The resulting mixture is diluted with methylene chloride and filtered. Evaporation of the filtrate in vacuo yields an oil which is dissolved in carbon tetrachloride (4 ml.), washed with water (2 × 2 ml.) and saturated brine (4 ml.), dried over magnesium sulfate, and evaporated in vacuo to yield p-methoxybenzyl 5-methyl-6H-1,3-thiazine-4-carboxylate (35 mg.) as a yellow oil.

1. filtrationfiltered
2. customEvaporation of the filtrate in vacuo
3. customyields an oil which
4. washwashed with water (2 × 2 ml.) and saturated brine (4 ml.)
5. dry with materialdried over magnesium sulfate
6. customevaporated in vacuo