反应详情

Azidoacetic acid (5.35 g, 0.05 mole) and mercuric acetate (1.82 g, 5.7 mMoles) are added to 50 ml of methylene chloride containing 0.1 ml of boron trifluoride etherate. Propyne, which had been passed through Linde Co. Molecular Sieves 4A, is bubbled slowly through the mixture for 3 hours. Sodium bicarbonate (0.5 g) is added and the mixture is filtered through a short Florisil column. The eluent is concentrated in vacuo and the residue obtained is purified by vacuum distillation to give isopropenyl azidoacetate.

1. customMolecular Sieves 4A, is bubbled slowly through the mixture for 3 hours
2. additionSodium bicarbonate (0.5 g) is added
3. filtrationthe mixture is filtered through a short Florisil column
4. concentrationThe eluent is concentrated in vacuo
5. customthe residue obtained
6. distillationis purified by vacuum distillation