HCID 21529908, compound → HCID 12669615, compound

HRID 1658018Notes

Reaction equation

HRID 1658018 reaction equation
[ClH:1].C([NH:9][CH2:10][P:11](=[O:26])([O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)C1C=CC=CC=1>[Pd].C(O)C>[ClH:1].[NH2:9][CH2:10][P:11](=[O:26])([O:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 1

HCID 21529908HCID 21529908, compound

Product 1

HCID 12669615HCID 12669615, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of diphenyl N-benzyl-aminomethylphosphonate hydrochloride (185.0 g), 10% palladium on carbon (7.0 g), and ethanol (1500 ml) is hydrogenated at 40 psi until hydrogen absorption ceases. The catalyst is removed by filtration through a pad of super cel and the filtrate is evaporated under reduced pressure to give diphenyl aminomethylphosphonate hydrochloride.

Workup

  1. customis hydrogenated at 40 psi until hydrogen absorption
  2. customThe catalyst is removed by filtration through a pad of super cel
  3. customthe filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-08ab3f80ad7c4850b698052b95bdf365
Source dataset
uspto-grants-1976_06
Patent number
US03962224

Reaction notes

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