Methane → HCID 13310505, compound

HRID 1658026Notes

Reaction equation

HRID 1658026 reaction equation
[ClH:1].C([NH:9][CH2:10][P:11](=[O:16])([O:14][CH3:15])[O:12][CH3:13])C1C=CC=CC=1.C>CO.C1C=CC=CC=1.[Pd]>[ClH:1].[NH2:9][CH2:10][P:11](=[O:16])([O:14][CH3:15])[O:12][CH3:13]

Participants

6

Reactant 2

HCID 297MethaneHCID 21529923HCID 21529923, compound

Product 1

HCID 13310505HCID 13310505, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 241BenzeneSolventHCID 887MethanolSolvent

Procedure

Dimethyl N-benzyl-aminomethylphosphonate hydrochloride (80.0 g) in methanol (800 ml) is hydrogenated at 40 psi with 10% palladium on powdered charcoal (4.0 g). The catalyst is removed by filtration through a pad of super cel. Evaporation of the methanolic filtrate gives a clear residue which is taken up in benzene. Removal of the benzene in vacuo affords crystalline dimethyl aminomethylphosphonate hydrochloride.

Workup

  1. customThe catalyst is removed by filtration through a pad of super cel
  2. customEvaporation of the methanolic filtrate
  3. customgives a clear residue which
  4. customRemoval of the benzene in vacuo

Sources & evidence

ORD record
ord-6718af19d98247e983271e20463a484f
Source dataset
uspto-grants-1976_06
Patent number
US03962224

Reaction notes

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