反应详情

Dimethyl N-benzyl-aminomethylphosphonate hydrochloride (80.0 g) in methanol (800 ml) is hydrogenated at 40 psi with 10% palladium on powdered charcoal (4.0 g). The catalyst is removed by filtration through a pad of super cel. Evaporation of the methanolic filtrate gives a clear residue which is taken up in benzene. Removal of the benzene in vacuo affords crystalline dimethyl aminomethylphosphonate hydrochloride.

1. customThe catalyst is removed by filtration through a pad of super cel
2. customEvaporation of the methanolic filtrate
3. customgives a clear residue which
4. customRemoval of the benzene in vacuo