反应详情

p-Methoxybenzyl N-benzylidene-α-amino-dimethylphosphonoacetate (9.78 g) in ether (50 ml) is added over 20 minutes to a stirring solution of p-toluenesulfonic acid monohydrate (4.76 g) in ether (150 ml). Cyclohexane (100 ml) is added and the solvents are decanted off. The residue is washed with more 2:1 ether-cyclohexane, which is again decanted off. The residue is partitioned between methylene chloride and 1 M dipotassium hydrogen phosphate (50 ml). The organic portion is separated, washed with water, dried, and evaporated in vacuo to give p-methoxybenzyl α-aminodimethylphosphonoacetate.

1. customthe solvents are decanted off
2. washThe residue is washed with more 2:1 ether-cyclohexane, which
3. customis again decanted off
4. customThe residue is partitioned between methylene chloride and 1 M dipotassium hydrogen phosphate (50 ml)
5. customThe organic portion is separated
6. washwashed with water
7. customdried
8. customevaporated in vacuo