Methanol → HCID 53872663, compound

HRID 1658044Notes

Reaction equation

HRID 1658044 reaction equation
[Na].CO[CH:4]([CH3:7])[C:5]#[N:6].[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:15]=[C:16]2[O:20][CH2:19][O:18][C:17]=12)[CH:13]=O.[CH3:21][OH:22]>>[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:15]=[C:16]2[O:20][CH2:19][O:18][C:17]=12)[CH:13]=[C:4]([CH2:7][O:22][CH3:21])[C:5]#[N:6]

Participants

5

Reactant 4

HCID 887Methanol2×HCID 220161,3-Benzodioxole-5-carboxaldehyde, 7-methoxy-HCID 1418292-MethoxypropanenitrileHCID 5360545Sodium

Product 1

HCID 53872663HCID 53872663, compound

Procedure

3.8 g. of sodium were dissolved in 120 ml. of methanol under reflux. 56 g. of methoxypropionitrile and 60 g. of 3-methoxy-4,5-methylenedioxybenzaldehyde were then added and refluxed in the methanol mixture for 5 hours. Upon chilling, 3-methoxy-4,5-methylenedioxy-α-methoxymethyl-cinnamonitrile crystallized in needles of m.p. = 115°, in a yield of 68 g. = 83 percent. A sample of analysis was recrystallized from methanol, m.p. 115.5°-116.5°.

Workup

  1. temperatureUpon chilling
  2. custom3-methoxy-4,5-methylenedioxy-α-methoxymethyl-cinnamonitrile crystallized in needles of m.p. = 115°, in a yield of 68 g
  3. customA sample of analysis was recrystallized from methanol, m.p. 115.5°-116.5°

Sources & evidence

ORD record
ord-7d46f5eb344942c394e504ee91dd2aa3
Source dataset
uspto-grants-1976_06
Patent number
US03962435

Reaction notes

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