Potassium thiocyanate → HCID 21532596, compound

HRID 1658055Notes

Reaction equation

HRID 1658055 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[N:12]=[C:11](Cl)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[S-:16][C:17]#[N:18].[K+]>C(O)(=O)C>[F:1][C:2]([F:15])([F:14])[C:3]1[N:12]=[C:11]([S:16][C:17]#[N:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 14754354-Chloro-2-(trifluoromethyl)quinazoline

Product 1

HCID 21532596HCID 21532596, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

46.5 g of 2-trifluoromethyl-4-chloro-quinazoline is added, while stirring, to a mixture of 97 g of potassiumthiocyanate and 200 ml of acetic acid. The reaction mixture is stirred for 2 hours at room temperature, the resultant light-yellow precipitate is drawn off, consecutively washed with a small amount of acetic acid and water and subsequently dried in air. The 2-trifluoromethyl-4-thiocyano-quinazoline thus obtained has a melting point of 134°-136°C.

Workup

  1. washconsecutively washed with a small amount of acetic acid and water
  2. customsubsequently dried in air

Sources & evidence

ORD record
ord-5c6db7bb4bd44fe7a185c83560556bac
Source dataset
uspto-grants-1976_06
Patent number
US03962444

Reaction notes

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