Potassium thiocyanate → HCID 21532590, compound

HRID 1658056Notes

Reaction equation

HRID 1658056 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]([F:17])([F:16])[CH:13]([F:15])[F:14])[N:3]=1.[K].[S-:19][C:20]#[N:21].[S-]C#N.[K+]>C(O)(=O)C>[S:19]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]([F:17])([F:16])[CH:13]([F:15])[F:14])[N:3]=1)[C:20]#[N:21]

Participants

5

Reactant 3

HCID 516872Potassium thiocyanateHCID 21532594HCID 21532594, compoundHCID 131710325HCID 131710325, compound

Product 1

HCID 21532590HCID 21532590, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

7.9 g of 4-chloro-2-(1,1,2,2-tetrafluoroethyl)-quinazoline are dissolved in 10 ml of glacial acetic acid and subsequently 4.9 g of potassium-thiocyanate are added to this solution. Whilst stirring at room temperature the potassium thiocyanate dissolves in approximately 1 hour. The solution is stirred for another 2 hours, a precipitation being obtained. This precipitation is drawn off, washed with water and dried in vacuo. After recrystallization from isoporpanol the resulting 4-thiocyano-2-(1,1,2,2-tetrafluoro-ethyl)-quinazoline has a melting point of 112°-114.5°C.

Workup

  1. dissolutiondissolves in approximately 1 hour
  2. customa precipitation
  3. custombeing obtained
  4. customThis precipitation
  5. washwashed with water
  6. customdried in vacuo
  7. customAfter recrystallization from isoporpanol the resulting 4-thiocyano-2-(1,1,2,2-tetrafluoro-ethyl)-quinazoline

Sources & evidence

ORD record
ord-ac85bc4f6fb34e9cb2fb3f8e6036af8f
Source dataset
uspto-grants-1976_06
Patent number
US03962444

Reaction notes

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