Potassium thiocyanate → HCID 21532590, compound

Participants

Reaction Steps

7.9 g of 4-chloro-2-(1,1,2,2-tetrafluoroethyl)-quinazoline are dissolved in 10 ml of glacial acetic acid and subsequently 4.9 g of potassium-thiocyanate are added to this solution. Whilst stirring at room temperature the potassium thiocyanate dissolves in approximately 1 hour. The solution is stirred for another 2 hours, a precipitation being obtained. This precipitation is drawn off, washed with water and dried in vacuo. After recrystallization from isoporpanol the resulting 4-thiocyano-2-(1,1,2,2-tetrafluoro-ethyl)-quinazoline has a melting point of 112°-114.5°C.

Provenance & Evidence