Diphenyl Ether → HCID 12223713, compound

HRID 1658059Notes

Reaction equation

HRID 1658059 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:16]=[C:15]2[C:6]([S:7][C:8]3[CH:9]=[CH:10][CH:11]=[C:12]([C:17]([N:19]=[C:20]=[S:21])=[O:18])[C:13]=3[NH:14]2)=[CH:5][CH:4]=1.C1(OC2C=CC=CC=2)C=CC=CC=1>C1(C)C=CC=CC=1>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[S:7][C:8]3[C:13]4=[C:12]([C:17](=[O:18])[NH:19][C:20](=[S:21])[N:14]4[C:15]=2[CH:16]=1)[CH:11]=[CH:10][CH:9]=3

Participants

4

Reactant 2

HCID 7583Diphenyl EtherHCID 12223712HCID 12223712, compound

Product 1

HCID 12223713HCID 12223713, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A slurry of 53.7 g. (0.168 mol.) of 8-trifluoromethylphenothiazine-1-carboxylic acid isothiocyanate in 30 ml. of diphenyl ether was heated in an oil bath at 210° for one hour. The reaction mixture first became a homogenous liquid and then turned into a solid mass. The cooled reaction mixture was refluxed for several minutes in 100 ml. of toluene, cooled to ambient temperature, and the insoluble material was collected by filtration and washed with several small portions of toluene to give the title compound, m.p. 297°-299° (ethanol).

Workup

  1. customThe cooled reaction mixture
  2. temperaturewas refluxed for several minutes in 100 ml
  3. filtrationthe insoluble material was collected by filtration
  4. washwashed with several small portions of toluene

Sources & evidence

ORD record
ord-51ead5dfeea14c099b26cd35a8f0bdb9
Source dataset
uspto-grants-1976_06
Patent number
US03962438

Reaction notes

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