Hydrochloric Acid → HCID 12223719, compound

HRID 1658065Notes

Reaction equation

HRID 1658065 reaction equation
C([O:4][CH:5]([CH2:30][O:31]C(=O)C)[CH2:6][N:7]1[C:27](=[O:28])[C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[S:16][C:17]4[CH:18]=[CH:19][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:21][C:22]=4[N:9]([C:10]=23)[C:8]1=[O:29])(=O)C.Cl>CO>[OH:4][CH:5]([CH2:30][OH:31])[CH2:6][N:7]1[C:27](=[O:28])[C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[S:16][C:17]4[CH:18]=[CH:19][C:20]([C:23]([F:24])([F:25])[F:26])=[CH:21][C:22]=4[N:9]([C:10]=23)[C:8]1=[O:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12223718HCID 12223718, compound

Product 1

HCID 12223719HCID 12223719, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 48.1 g. (0.0975 mol.) of 2-(2,3-diacetoxypropyl)-10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-dione in 200 ml. of methanol and 25 ml. of concentrated hydrochloric acid was heated under reflux for 0.5 hour, then allowed to stand overnight at ambient temperature. The white solid that precipitated was isolated by filtration and washed with water to give the title compound, m.p. 159°-162° (chloroform).

Workup

  1. additionA mixture of 48.1 g
  2. temperatureunder reflux for 0.5 hour
  3. customThe white solid that precipitated
  4. customwas isolated by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-c93018c279aa40fc8fc5f0a2a1d5b800
Source dataset
uspto-grants-1976_06
Patent number
US03962438

Reaction notes

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