m-Chloroperbenzoic acid → HCID 12223720, compound

HRID 1658066Notes

Reaction equation

HRID 1658066 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.[F:12][C:13]([F:34])([F:33])[C:14]1[CH:27]=[CH:26][C:25]2[S:24][C:23]3[C:18]4=[C:19]([C:28](=[O:32])[NH:29][C:30](=[O:31])[N:17]4[C:16]=2[CH:15]=1)[CH:20]=[CH:21][CH:22]=3>CO>[F:34][C:13]([F:33])([F:12])[C:14]1[CH:27]=[CH:26][C:25]2[S:24](=[O:9])[C:23]3[C:18]4=[C:19]([C:28](=[O:32])[NH:29][C:30](=[O:31])[N:17]4[C:16]=2[CH:15]=1)[CH:20]=[CH:21][CH:22]=3

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 1222371510-Trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3-(2H)-dione

Product 1

HCID 12223720HCID 12223720, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

m-Chloroperbenzoic acid (1.9 g., 0.011 mol.) was added portion-wise to a cold (0-5°), stirred solution of 3.36 g. (0.01 mol.) of 10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-dione in 35 ml. of absolute methanol. The reaction mixture was stirred in the cold for one hour, then an additional four hours at ambient temperature. The reaction mixture was chilled and the precipitated product was collected by filtration and washed with ice-cold methanol to give the title compound, m.p. 302-304° (methanol).

Workup

  1. stirringThe reaction mixture was stirred in the cold for one hour
  2. customan additional four hours
  3. customat ambient temperature
  4. temperatureThe reaction mixture was chilled
  5. filtrationthe precipitated product was collected by filtration
  6. washwashed with ice-cold methanol

Sources & evidence

ORD record
ord-a26c12608b9e43d2bd4f64e406153a16
Source dataset
uspto-grants-1976_06
Patent number
US03962438

Reaction notes

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