Acetic Acid → HCID 12223721, compound

HRID 1658070Notes

Reaction equation

HRID 1658070 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7]4=[C:8]([C:17](=[O:21])[NH:18][C:19](=[O:20])[N:6]4[C:5]=2[CH:4]=1)[CH:9]=[CH:10][CH:11]=3.[H][H].C(O)(=[O:28])C.[OH2:30]>>[F:23][C:2]([F:22])([F:1])[C:3]1[CH:16]=[CH:15][C:14]2[S:13](=[O:28])(=[O:30])[C:12]3[C:7]4=[C:8]([C:17](=[O:21])[NH:18][C:19](=[O:20])[N:6]4[C:5]=2[CH:4]=1)[CH:9]=[CH:10][CH:11]=3

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 1222371510-Trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3-(2H)-dioneHCID 178418361HCID 178418361, compound

Product 1

HCID 12223721HCID 12223721, compound

Procedure

A mixture of 3.36 g. (0.01 mol.) of 10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-dione and three equivalents of 30% hydrogen perioxide in 70 ml. of glacial acetic acid was heated at 75°-85° for 4 hours. The reaction mixture was cooled and diluted with water. The precipitated product was collected by filtration and washed with water to give the title compound, m.p. 290 -293° (methanol).

Workup

  1. additionA mixture of 3.36 g
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe precipitated product was collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-77c89bfaa6c740e2aaaeef73703a2f41
Source dataset
uspto-grants-1976_06
Patent number
US03962438

Reaction notes

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