反应详情

Sodium (0.115 g.) was dissolved carefully in methanol (45 ml.) and 3-cyanopyridine (5.2 g.) was added. Next day, acetic acid (0.3 g.) was added followed by 2-(3-amino-4-hydroxyphenyl)propionic acid (9.05 g.). The stirred mixture was heated under reflux for 5 hours. The solid dissolved completely during this time. An equal volume of water was added to the hot solution. On cooling, cream crystals separated which were filtered off and re-crystallised from dimethylformamide-ethanol to yield the desired acid, m.p. 197°- 200°C.

1. temperatureThe stirred mixture was heated
2. temperatureunder reflux for 5 hours
3. dissolutionThe solid dissolved completely during this time
4. temperatureOn cooling
5. customcream crystals separated which
6. filtrationwere filtered off
7. customre-crystallised from dimethylformamide-ethanol