1-Methylpiperazine → HCID 12379019, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing 1.33 g of 5,8-dihydro-8-ethyl-2-methylthio-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid, 1.30 g of 4-methylpiperazine, and 20 ml of dimethyl sulfoxide was heated at 110°C for 1 hour with stirring. The separated solid was collected by filtration, washed with ethanol, and recrystallized from dimethylformamide to give 1.86 g of the product, as nearly coloress needles, m.p. 232 - 233°C.

Provenance & Evidence