1-Methylpiperazine → HCID 12379019, compound

HRID 1658112Notes

Reaction equation

HRID 1658112 reaction equation
[CH2:1]([N:3]1[C:8]2[N:9]=[C:10](SC)[N:11]=[CH:12][C:7]=2[C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4]1)[CH3:2].[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>CS(C)=O>[CH2:1]([N:3]1[C:8]2[N:9]=[C:10]([N:23]3[CH2:24][CH2:25][N:20]([CH3:19])[CH2:21][CH2:22]3)[N:11]=[CH:12][C:7]=2[C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 12649649HCID 12649649, compound

Product 1

HCID 12379019HCID 12379019, compoundYield 116.9%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
110 °C

Procedure

A mixture containing 1.33 g of 5,8-dihydro-8-ethyl-2-methylthio-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid, 1.30 g of 4-methylpiperazine, and 20 ml of dimethyl sulfoxide was heated at 110°C for 1 hour with stirring. The separated solid was collected by filtration, washed with ethanol, and recrystallized from dimethylformamide to give 1.86 g of the product, as nearly coloress needles, m.p. 232 - 233°C.

Workup

  1. filtrationThe separated solid was collected by filtration
  2. washwashed with ethanol
  3. customrecrystallized from dimethylformamide

Sources & evidence

ORD record
ord-ea441fc3e3a648e28f17e1c6d961c6df
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

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