Piperazine, hexahydrate → HCID 12884179, compound

HRID 1658113Notes

Reaction equation

HRID 1658113 reaction equation
CS[C:3]1[N:4]=[CH:5][C:6]2[C:12](=[O:13])[C:11]([C:14]([OH:16])=[O:15])=[CH:10][N:9]([CH2:17][CH2:18][CH3:19])[C:7]=2[N:8]=1.O.O.O.O.O.O.[NH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>CS(C)=O>[N:26]1([C:3]2[N:4]=[CH:5][C:6]3[C:12](=[O:13])[C:11]([C:14]([OH:16])=[O:15])=[CH:10][N:9]([CH2:17][CH2:18][CH3:19])[C:7]=3[N:8]=2)[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1

Participants

4

Reactant 2

HCID 120181Piperazine, hexahydrateHCID 21532584HCID 21532584, compound

Product 1

HCID 12884179HCID 12884179, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A mixture containing 1.40 g of 5,8-dihydro-2-methylthio-8-n-propyl-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid, 2.94 g of piperazine hexahydrate, and 20 ml of dimethylsulfoxide was heated at 100 - 110°C for 1.5 hours. The precipitate was collected, washed with ethanol, and then recrystallized from water to yield 1.40 g of the product, as colorless needles, m.p. 259°- 261°C.

Workup

  1. temperaturewas heated at 100 - 110°C for 1.5 hours
  2. customThe precipitate was collected
  3. washwashed with ethanol
  4. customrecrystallized from water

Sources & evidence

ORD record
ord-fe9756b4f19841b99921df1ba29747b7
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

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