Ethanol → Potassium 8-ethyl-5,8-dihydro-5-oxo-2-(piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylate

HRID 1658115Notes

Reaction equation

HRID 1658115 reaction equation
C(=O)([O-])[O-].[K+:5].[K+].[CH2:7]([N:9]1[C:14]2[N:15]=[C:16]([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:17]=[CH:18][C:13]=2[C:12](=[O:25])[C:11]([C:26]([OH:28])=[O:27])=[CH:10]1)[CH3:8].C(O)C>O>[CH2:7]([N:9]1[C:14]2[N:15]=[C:16]([N:19]3[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]3)[N:17]=[CH:18][C:13]=2[C:12](=[O:25])[C:11]([C:26]([O-:28])=[O:27])=[CH:10]1)[CH3:8].[K+:5]

Participants

5

Reactant 3

HCID 702EthanolHCID 4831Pipemidic AcidHCID 11430Potassium Carbonate

Product 1

HCID 23684590Potassium 8-ethyl-5,8-dihydro-5-oxo-2-(piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylateYield 61.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of potassium carbonate (2.76 g) in 60 ml of water was added 6.06 g of 5,8-dihydro-8-ethyl-2-(1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid. The resulting mixture was heated on a steam bath until it became a clear solution. Ethanol was added to the solution, and the mixture was then kept below room temperature by external cooling to yield the precipitate, which was collected and washed with ethanol. There is obtained 4.2 g of the product m.p. above 300°C.

Workup

  1. temperatureThe resulting mixture was heated on a steam bath until it
  2. customwas then kept below room temperature
  3. temperatureby external cooling
  4. customto yield the precipitate, which
  5. customwas collected
  6. washwashed with ethanol

Sources & evidence

ORD record
ord-55cce28b485443d0a9328cfe4588ebe4
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

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