Diphenyl Ether → HCID 15574553, compound

HRID 1658118Notes

Reaction equation

HRID 1658118 reaction equation
C1(OC2C=CC=CC=2)C=CC=CC=1.[CH3:14][N:15]1[CH2:20][CH2:19][N:18]([C:21]2[N:26]=[C:25]([NH:27][CH:28]=[C:29]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[C:30](OCC)=[O:31])[CH:24]=[CH:23][N:22]=2)[CH2:17][CH2:16]1>CCCCCC>[CH3:14][N:15]1[CH2:16][CH2:17][N:18]([C:21]2[N:22]=[CH:23][C:24]3[C:30](=[O:31])[C:29]([C:35]([O:37][CH2:38][CH3:39])=[O:36])=[CH:28][NH:27][C:25]=3[N:26]=2)[CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 7583Diphenyl EtherHCID 15574552HCID 15574552, compound

Product 1

HCID 15574553HCID 15574553, compoundYield 103.1%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

To a 50 ml of diphenyl ether heated at 210° - 220°C was added with stirring 7.0 g of diethyl N-[2-(4-methyl-1-piperazinyl)-4-pyrimidinyl]aminomethylenemalonate, and heating was continued for 1 hour. To the resulting mixture, after being cooled, was added 50 ml of n-hexane. The resulting precipitate was collected, washed with ethanol, and recrystallized from dimethylformamide to yield 6.3 g of the product, m.p. 266° - 268°C.

Workup

  1. additionwas added
  2. temperatureheating
  3. temperatureTo the resulting mixture, after being cooled
  4. customThe resulting precipitate was collected
  5. washwashed with ethanol
  6. customrecrystallized from dimethylformamide

Sources & evidence

ORD record
ord-be5d63fae8e54a7eae759e2f4e6b8a01
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

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