Iodoethane → HCID 12266831, compound

HRID 1658127Notes

Reaction equation

HRID 1658127 reaction equation
C([O:3][C:4]1[C:13]2[CH:12]=[N:11][C:10]([N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)=[N:9][C:8]=2[N:7]=[CH:6][C:5]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22])C.[CH2:26](I)[CH3:27]>>[CH2:26]([N:7]1[C:8]2[N:9]=[C:10]([N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)[N:11]=[CH:12][C:13]=2[C:4](=[O:3])[C:5]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:6]1)[CH3:27]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 21532573HCID 21532573, compound

Product 1

HCID 12266831HCID 12266831, compound

Procedure

A mixture containing 1.0 g of ethyl 5-ethoxy-2-(4-methyl-1-piperazinyl)pyrido[2,3-d]pyrimidine-6-carboxylate and 5.0 ml of ethyl iodide was heated to reflux for one hour. After ethyl iodide was recovered by distillation, the resulting solid was crystallized from water to give 0.69 g of the product, m.p. 146° - 147°C.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for one hour
  3. distillationAfter ethyl iodide was recovered by distillation
  4. customthe resulting solid was crystallized from water

Sources & evidence

ORD record
ord-6d8803efa44d441faacff9e623edd6f8
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

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