Hydrochloric Acid → 8-Ethyl-5,8-dihydro-5-oxo-2-(piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid hydrochloride

HRID 1658135Notes

Reaction equation

HRID 1658135 reaction equation
[CH2:1]([N:3]1[C:8]2[N:9]=[C:10]([N:13]3[CH2:18][CH2:17][N:16](C=O)[CH2:15][CH2:14]3)[N:11]=[CH:12][C:7]=2[C:6](=[O:21])[C:5]([C:22]([OH:24])=[O:23])=[CH:4]1)[CH3:2].[ClH:25]>>[ClH:25].[CH2:1]([N:3]1[C:8]2[N:9]=[C:10]([N:13]3[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]3)[N:11]=[CH:12][C:7]=2[C:6](=[O:21])[C:5]([C:22]([OH:24])=[O:23])=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 133347415,8-Dihydro-8-ethyl-2-(4-formyl-1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid

Product 1

HCID 64525688-Ethyl-5,8-dihydro-5-oxo-2-(piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid hydrochloride

Procedure

A mixture containing, 2.0 g of 5,8-dihydro-8-ethyl-2-(4-formyl-1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid and 30 ml of 10% aqueous hydrochloric acid was heated at 90° - 95°C for 1 hour. The reaction mixture was concentrated to dryness and addition of ethanol to the residue resulted in the separation of a solid, which was collected and washed with ethanol to yield 1.7 g of the product, m.p. above 300°C.

Workup

  1. additionA mixture containing
  2. concentrationThe reaction mixture was concentrated to dryness and addition of ethanol to the residue
  3. customresulted in the separation of a solid, which
  4. customwas collected
  5. washwashed with ethanol

Sources & evidence

ORD record
ord-1c78462746d942e9a3fc488b4f4dff50
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

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