反应详情

A mixture containing, 2.0 g of 5,8-dihydro-8-ethyl-2-(4-formyl-1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid and 30 ml of 10% aqueous hydrochloric acid was heated at 90° - 95°C for 1 hour. The reaction mixture was concentrated to dryness and addition of ethanol to the residue resulted in the separation of a solid, which was collected and washed with ethanol to yield 1.7 g of the product, m.p. above 300°C.

1. additionA mixture containing
2. concentrationThe reaction mixture was concentrated to dryness and addition of ethanol to the residue
3. customresulted in the separation of a solid, which
4. customwas collected
5. washwashed with ethanol