HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-(2-Chloroethyl)-5,8-dihydro-2-(1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 2-(4-acetyl-1-piperazinyl)-8-(2-chloroethyl)-5,8-dihydro-5-oxopyrido[2,3-d]-pyrimidine-6-carboxylate | HCID 13334740 | — |
| Product | 8-(2-Chloroethyl)-5,8-dihydro-2-(1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid hydrochloride | HCID 68148669 | 196.2% |
Reaction Steps
A mixture containing 1.0 g of ethyl 2-(4-acetyl-1-piperazinyl)-8-(2-chloroethyl)-5,8-dihydro-5-oxopyrido[2,3-d]-pyrimidine-6-carboxylate and 12 ml of 20% aqueous hydrochloric acid was heated on a steam bath for 2 hours, during which period crystals separated out. The crystals were collected, after cooling, and recrystallized from diluted aqueous ethanol containing a small amount of concentrated hydrochloric acid to yield 0.9 g of the product, m.p. 280°C with decomposition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03962443 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-d2d201fdb79e469cab4b309c7379e1ac |
| Source note | uspto-grants-1976_06 |