反应详情

A mixture containing 1.0 g of ethyl 2-(4-acetyl-1-piperazinyl)-8-(2-chloroethyl)-5,8-dihydro-5-oxopyrido[2,3-d]-pyrimidine-6-carboxylate and 12 ml of 20% aqueous hydrochloric acid was heated on a steam bath for 2 hours, during which period crystals separated out. The crystals were collected, after cooling, and recrystallized from diluted aqueous ethanol containing a small amount of concentrated hydrochloric acid to yield 0.9 g of the product, m.p. 280°C with decomposition.

1. temperaturewas heated on a steam bath for 2 hours, during which period crystals
2. customseparated out
3. customThe crystals were collected
4. temperatureafter cooling
5. customrecrystallized from diluted aqueous ethanol containing a small amount of concentrated hydrochloric acid