Hydrochloric Acid → HCID 12379023, compound

HRID 1658138Notes

Reaction equation

HRID 1658138 reaction equation
Cl[CH2:2][CH2:3][N:4]1[C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)[N:12]=[CH:13][C:8]=2[C:7](=[O:21])[C:6]([C:22]([OH:24])=[O:23])=[CH:5]1.[OH-].[Na+].Cl>>[CH3:20][N:17]1[CH2:18][CH2:19][N:14]([C:11]2[N:12]=[CH:13][C:8]3[C:7](=[O:21])[C:6]([C:22]([OH:24])=[O:23])=[CH:5][N:4]([CH:3]=[CH2:2])[C:9]=3[N:10]=2)[CH2:15][CH2:16]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12917700HCID 12917700, compound

Product 1

HCID 12379023HCID 12379023, compoundYield 70.3%

Procedure

A solution of 8-(2-chloroethyl)-5,8 -dihydro-2-(4-methyl-1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid (1.0 g) in 20 ml of a 10% aqueous solution of sodium hydroxide was heated at 95°C for three hours. The reaction mixture was then neutralized with hydrochloric acid under ice-cooling and chilled. The resulting precipitate was collected to give 0.63 g of the product. Recrystallization from a mixture of chloroform and ethanol gave the product as pure state.

Workup

  1. temperaturecooling
  2. temperaturechilled
  3. customThe resulting precipitate was collected

Sources & evidence

ORD record
ord-d98a3c4619664b08bdb404fc6ca05db3
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

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