Chloroacetyl chloride → 2-chloro-N-(2-chloro-4-sulfamoylphenyl)acetamide

HRID 1658200Notes

Reaction equation

[Cl:1][C:2]1[CH:8]=[C:7]([S:9](=[O:12])(=[O:11])[NH2:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[Cl:13][CH2:14][C:15](Cl)=[O:16]>>[Cl:13][CH2:14][C:15]([NH:4][C:3]1[CH:5]=[CH:6][C:7]([S:9](=[O:12])(=[O:11])[NH2:10])=[CH:8][C:2]=1[Cl:1])=[O:16]

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 15020144-Amino-3-chlorobenzenesulfonamide

Product 1

HCID 215288302-chloro-N-(2-chloro-4-sulfamoylphenyl)acetamide

Procedure

2-Chloro-4-sulphamoylaniline (50 g) and α-chloroacetyl chloride (24 ml) were refluxed together for 45 min. and the product worked up as in Example 2(a) to yield 59.5 g, m.p. 162°-164°

Workup

customto yield 59.5 g, m.p. 162°-164°

Sources & evidence

ORD record: ord-5724772342484e129e68f7fe4a05e641
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03963706

Reaction notes

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