Aniline → 2-Phenylamino-N-(2-bromo-4-sulphamoylphenyl)-acetamide

HRID 1658207Notes

Reaction equation

Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](=[O:15])(=[O:14])[NH2:13])=[CH:8][C:7]=1[Br:16])=[O:4].[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:18]1([NH:17][CH2:2][C:3]([NH:5][C:6]2[CH:11]=[CH:10][C:9]([S:12](=[O:15])(=[O:14])[NH2:13])=[CH:8][C:7]=2[Br:16])=[O:4])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

Reactant 2

HCID 6115Aniline

HCID 215288442-Chloro-N-(2-bromo-4-sulphamoylphenyl)-acetamide

Product 1

HCID 215288692-Phenylamino-N-(2-bromo-4-sulphamoylphenyl)-acetamideYield 80.6%

Procedure

2-Chloro-N-(2-bromo-4-sulphamoylphenyl)-acetamide (16.4g) and aniline (9.0 g) were heated together for 60 min. on a water bath at 90° the product was worked up as in Example 1(b) to yield 15,5 g beige crystals m.p.: 179°-181°.

Sources & evidence

ORD record: ord-7f522b9ec886475ab74dca5c6c79b908
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03963706

Reaction notes

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