Formaldehyde → S 332

HRID 1658210Notes

Reaction equation

HRID 1658210 reaction equation
[C:1]1([NH:7][CH2:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18](=[O:21])(=[O:20])[NH2:19])=[CH:14][C:13]=2[CH3:22])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:23]=O>O>[C:1]1([N:7]2[CH2:8][C:9](=[O:10])[N:11]([C:12]3[CH:17]=[CH:16][C:15]([S:18](=[O:21])(=[O:20])[NH2:19])=[CH:14][C:13]=3[CH3:22])[CH2:23]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 215288562-Phenylamino-N-(2-methyl-4-sulphamoylphenyl)-acetamide

Product 1

HCID 3041006S 332

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Phenylamino-N-(2-methyl-4-sulphamoylphenyl)-acetamide (16 g) was dissolved in ethano, (320 ml) and paraformaldehyde (1.9 g) in water (640 ml) added. The mixture was refluxed 11/2 hr, cooled and filtered. The residue was crystallised from DMF/water to yield 16 g, m.p. 206°-210°.

Workup

  1. additionadded
  2. temperatureThe mixture was refluxed 11/2 hr
  3. temperaturecooled
  4. filtrationfiltered
  5. customThe residue was crystallised from DMF/water
  6. customto yield 16 g, m.p. 206°-210°

Sources & evidence

ORD record
ord-ca44e57fe5494e11997c588ad231df62
Source dataset
uspto-grants-1976_06
Patent number
US03963706

Reaction notes

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