Ethanol → Benzenesulfonamide, 4-(5-oxo-3-phenyl-1-imidazolidinyl)-2-(trifluoromethyl)-

HRID 1658212Notes

Reaction equation

HRID 1658212 reaction equation
[C:1]1([NH:7][CH2:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18](=[O:21])(=[O:20])[NH2:19])=[C:14]([C:22]([F:25])([F:24])[F:23])[CH:13]=2)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:26](O)C.C=O>O>[C:1]1([N:7]2[CH2:8][C:9](=[O:10])[N:11]([C:12]3[CH:17]=[CH:16][C:15]([S:18](=[O:21])(=[O:20])[NH2:19])=[C:14]([C:22]([F:25])([F:23])[F:24])[CH:13]=3)[CH2:26]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 712FormaldehydeHCID 21528857HCID 21528857, compound

Product 1

HCID 3041007Benzenesulfonamide, 4-(5-oxo-3-phenyl-1-imidazolidinyl)-2-(trifluoromethyl)-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Phenylamino-N-(3-trifluoromethyl-4-sulphamoylphenyl)-acetamide (11.2g) was added to ethanol (200 ml) and paraformaldehyde (1.3g) in water (400 ml) added thereto under reflux. The mixture was refluxed 11/2 hr, cooled and worked up as in Example 6(c) to yield 11,8 g, m.p. 235°-238°.

Workup

  1. additionadded
  2. temperatureunder reflux
  3. temperatureThe mixture was refluxed 11/2 hr
  4. temperaturecooled
  5. customto yield 11,8 g, m.p. 235°-238°

Sources & evidence

ORD record
ord-228ac984b1224e8ab8a2d968ee43975e
Source dataset
uspto-grants-1976_06
Patent number
US03963706

Reaction notes

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