Ethanol → Benzenesulfonamide, 3-chloro-4-(3-(4-methoxyphenyl)-5-oxo-1-imidazolidinyl)-

HRID 1658218Notes

Reaction equation

HRID 1658218 reaction equation
C[C:2]1[CH:23]=[CH:22][C:5]([NH:6][CH2:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([S:17](=[O:20])(=[O:19])[NH2:18])=[CH:13][C:12]=2[Cl:21])=[O:9])=[CH:4][CH:3]=1.[CH2:24]=O.[CH2:26]([OH:28])C>O>[CH3:26][O:28][C:2]1[CH:3]=[CH:4][C:5]([N:6]2[CH2:7][C:8](=[O:9])[N:10]([C:11]3[CH:16]=[CH:15][C:14]([S:17](=[O:19])(=[O:20])[NH2:18])=[CH:13][C:12]=3[Cl:21])[CH2:24]2)=[CH:22][CH:23]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 712FormaldehydeHCID 21528835HCID 21528835, compound

Product 1

HCID 3041011Benzenesulfonamide, 3-chloro-4-(3-(4-methoxyphenyl)-5-oxo-1-imidazolidinyl)-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product of stage a) (15g) was dissolved in ethanol (200 ml) and treated with paraformaldehyde (2.5g) in water (400 ml). The mixture was refluxed for 3 hours, cooled in ice/water and filtered to yield the title product (5 g), m.p. 221°-223°

Workup

  1. temperatureThe mixture was refluxed for 3 hours
  2. filtrationfiltered

Sources & evidence

ORD record
ord-8f4ca76e6cc94683a5126b83062eb037
Source dataset
uspto-grants-1976_06
Patent number
US03963706

Reaction notes

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