反应详情

To 5.2 parts of 2-(nitramino)-2-imidazoline is added a solution of 7.5 parts of α-(aminomethyl)-p-chlorobenzyl alcohol in 40 parts of xylene while heating. Upon completion, stirring is continued while heating in an oil-bath at 150°-160°C. and while the xylene is partly distilled off (till gas evolution ceases). The residue is cooled and after the addition of a few parts of acetone, the produce is allowed to crystallize. It is filtered off, washed successively with acetone and diisopropylether, dried and the product is recrystallized from 4-methyl-2-pentanone, yielding p-chloro-α-(2-imidazolin-2-ylaminomethyl)benzyl alcohol; m.p. 156°-158°C.

1. temperaturewhile heating
2. distillationis partly distilled off (till gas evolution ceases)
3. temperatureThe residue is cooled
4. additionafter the addition of a few parts of acetone
5. customto crystallize
6. filtrationIt is filtered off
7. washwashed successively with acetone and diisopropylether
8. customdried
9. customthe product is recrystallized from 4-methyl-2-pentanone