4-Bromophenacyl bromide → HCID 21510090, compound

HRID 1658265Notes

Reaction equation

HRID 1658265 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:4].[CH2:12]([NH:19][C:20]1[NH:21][CH2:22][CH2:23][N:24]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(C)=O>[BrH:1].[CH2:12]([N:19]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:4])[C:20]1[NH:24][CH2:23][CH2:22][N:21]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 74544-Bromophenacyl bromideHCID 18432815HCID 18432815, compound

Product 1

HCID 21510090HCID 21510090, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a stirred solution of 13.9 parts of 2,4'-dibromoacetophenone in 120 parts of acetone are added portionwise 8.75 parts of 2-(N-benzylamino)-2-imidazoline. Upon completion, stirring is continued for 2 days at room temperature. The precipitated product is filtered off, washed with acetone, dried and crystallized from ethanol, yielding 2-[N-benzyl-N-(2-imidazolin-2-yl)amino]-4'-bromoacetophenone hydrobromide, m.p. 262.9°C.

Workup

  1. filtrationThe precipitated product is filtered off
  2. washwashed with acetone
  3. customdried
  4. customcrystallized from ethanol

Sources & evidence

ORD record
ord-ac4a2c99f0c54488be69623adce76549
Source dataset
uspto-grants-1976_06
Patent number
US03963718

Reaction notes

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