反应详情

A mixture of 8 parts of α(2-aminoethyl)benzylalcohol, 7.2 parts of 2-(nitramino)- 1,4,5,6-tetrahydropyrimidine and 40 parts of xylene is stirred and refluxed for 48 hours with waterseparator. Upon cooling the reaction mixture, the product is separated as an oil. The xylene is decanted and the oily product is triturated in diisopropylether. The solid product is filtered off and crystallized from acetone, yielding α-[2-(1,4,5,6-tetrahydro-2-pyrimidinylamino)ethyl]benzylalcohol; m.p. 130°-135°C.

1. temperaturerefluxed for 48 hours with waterseparator
2. temperatureUpon cooling the reaction mixture
3. customthe product is separated as an oil
4. customThe xylene is decanted
5. customthe oily product is triturated in diisopropylether
6. filtrationThe solid product is filtered off
7. customcrystallized from acetone