Formaldehyde → HCID 21528955, compound

HRID 1658284Notes

Reaction equation

HRID 1658284 reaction equation
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]3[O:16][CH2:15][CH2:14][C:11]=3[CH:12]=2)[CH:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:6][C:5]1=[O:23])([CH3:3])[CH3:2].O1CCOCC1.[Mn]([O-])(=O)(=O)=O.[K+].C=O>O>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]3[O:16][CH2:15][CH2:14][C:11]=3[CH:12]=2)[C:7]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[N:6][C:5]1=[O:23])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 312751,4-DioxaneHCID 516875Potassium PermanganateHCID 21528969HCID 21528969, compound

Product 1

HCID 21528955HCID 21528955, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 4.6 g. of 1-isopropyl-3,4,7,8-tetrahydro-4-phenyl-furo[2,3-g]quinazolin-2(1H)-one in 200 ml. of dioxane cooled to 5°±5°C. is added dropwise a solution of 3.0 g. of potassium permanganate in 140 ml. of water. After the addition is completed 1.5 ml. of formalin solution is added. The resulting precipitated solids are removed by filtration and the filtrate concentrated in vacuo to obtain an oil of 1-isopropyl-7,8-dihydro-4-phenyl-furo[2,3-g]quinazolin-2(1H)-one.

Workup

  1. additionis added dropwise a solution of 3.0 g
  2. additionAfter the addition
  3. customThe resulting precipitated solids
  4. customare removed by filtration
  5. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-30bec1539f81491aaa331e9ca3b2dfb9
Source dataset
uspto-grants-1976_06
Patent number
US03963717

Reaction notes

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