Malonic Acid → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1658309Notes

Reaction equation

HRID 1658309 reaction equation
[CH3:1][C:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[NH:5][C:4]([CH3:11])([CH3:10])N=1.C(O)(=O)CC(O)=[O:15]>CC(C)=O>[CH3:10][C:4]1([CH3:11])[NH:5][C:6]([CH3:9])([CH3:8])[CH2:7][C:2](=[O:15])[CH2:1]1

Participants

4

Reactant 2

HCID 867Malonic AcidHCID 68396Pyrimidine, 1,2,5,6-tetrahydro-2,2,4,6,6-pentamethyl-

Product 1

HCID 132202,2,6,6-Tetramethyl-4-piperidoneYield 115%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 6.3 g. of acetonine in 40 g. of acetone was added with 0.5 g. of malonic acid and the mixture was heated at 60°C. for 10 hours in a sealed equipment to effect the reaction. After completion of the reaction, the reaction mixture was purified in the same manner as in Example 1 to obtain triacetonamine in a yield of 115%.

Workup

  1. customthe reaction
  2. customAfter completion of the reaction
  3. customthe reaction mixture was purified in the same manner as in Example 1

Sources & evidence

ORD record
ord-2e2ee25334ed4c46b29a9d2ac56005ac
Source dataset
uspto-grants-1976_06
Patent number
US03963730

Reaction notes

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