Acetone → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1658312Notes

Reaction equation

HRID 1658312 reaction equation
CC1CC(C)(C)NC(C)(C)N=1.CC(C)=O.[CH3:16][C:17]1([CH3:26])[NH:23][C:22]([CH3:25])([CH3:24])[CH2:21][C:19](=[O:20])[CH2:18]1.Cl>CO>[CH3:16][C:17]1([CH3:26])[NH:23][C:22]([CH3:25])([CH3:24])[CH2:21][C:19](=[O:20])[CH2:18]1

Participants

5

Reactant 3

HCID 180AcetoneHCID 68396Pyrimidine, 1,2,5,6-tetrahydro-2,2,4,6,6-pentamethyl-HCID 944522,2,6,6-Tetramethylpiperidin-4-one hydrochloride

Product 1

HCID 132202,2,6,6-Tetramethyl-4-piperidoneYield 115%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A solution of 5.0 g. of acetonine in a mixed solvent comprising 19 g. of acetone and 1.9 g. of methanol was added with 1.5 g. of triacetonamine hydrochloride. The mixture was heated at 60°C. for 10 hours in a sealed equipment to effect the reaction. After completion of the reaction, the reaction mixture was purified in the same manner as in Example 1 to obtain triacetonamine in a yield of 115% deducting the amount of triacetonamine used as catalyst.

Workup

  1. customthe reaction
  2. customAfter completion of the reaction
  3. customthe reaction mixture was purified in the same manner as in Example 1

Sources & evidence

ORD record
ord-0f72543ab9304a0eb1bbf1cf73d6b0fe
Source dataset
uspto-grants-1976_06
Patent number
US03963730

Reaction notes

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