Acetone → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1658313Notes

Reaction equation

HRID 1658313 reaction equation
[CH3:1][C:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[NH:5][C:4]([CH3:11])([CH3:10])N=1.CC(C)=[O:14].C([O-])(=O)C.[NH4+]>CO>[CH3:10][C:4]1([CH3:11])[NH:5][C:6]([CH3:9])([CH3:8])[CH2:7][C:2](=[O:14])[CH2:1]1

Participants

5

Reactant 3

HCID 180AcetoneHCID 68396Pyrimidine, 1,2,5,6-tetrahydro-2,2,4,6,6-pentamethyl-HCID 517165Ammonium Acetate

Product 1

HCID 132202,2,6,6-Tetramethyl-4-piperidoneYield 91.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5.0 g. of acetonine in a mixed solvent comprising 19 g. of acetone and 9.5 g. of methanol was added with 1.3 g. of ammonium acetate. The mixture was maintained at room temperature for 24 hours in a sealed equipment to effect the reaction. After completion of the reaction, the reaction mixture was purified in the same manner as in Example 1 to obtain triacetonamine in a yield of 91.1%.

Workup

  1. customthe reaction
  2. customAfter completion of the reaction
  3. customthe reaction mixture was purified in the same manner as in Example 1

Sources & evidence

ORD record
ord-94fa886b0ef34b8597038641fd407304
Source dataset
uspto-grants-1976_06
Patent number
US03963730

Reaction notes

Loading…