Acetone → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1658316Notes

Reaction equation

HRID 1658316 reaction equation
[CH3:1][C:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[NH:5][C:4]([CH3:11])([CH3:10])N=1.[Br-].[NH4+].CC(C)=[O:16]>>[CH3:10][C:4]1([CH3:11])[NH:5][C:6]([CH3:9])([CH3:8])[CH2:7][C:2](=[O:16])[CH2:1]1

Participants

4

Reactant 3

HCID 180AcetoneHCID 25514Ammonium BromideHCID 68396Pyrimidine, 1,2,5,6-tetrahydro-2,2,4,6,6-pentamethyl-

Product 1

HCID 132202,2,6,6-Tetramethyl-4-piperidoneYield 239%

Procedure

5 g. of Acetonine and 12.4 g. of ammonium bromide were added to 30 g. of acetone and the mixture was maintained at room temperature for 38 hours to effect the reaction. After completion of the reaction, the reaction mixture was purified in the same manner as in Example 1 to obtain triacetonamine in a yield of 239%.

Workup

  1. customthe reaction
  2. customAfter completion of the reaction
  3. customthe reaction mixture was purified in the same manner as in Example 1

Sources & evidence

ORD record
ord-021414862aa7489e8e7d61e2e879d530
Source dataset
uspto-grants-1976_06
Patent number
US03963730

Reaction notes

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