反应详情

By the procedure of Efxample 1, a solution of p-methoxybenzyl mercaptan in dimethylsulfoxide is added slowly to a stirred suspension of sodium hydride in dry dimethylsulfoxide under nitrogen. After stirring for one hour at room temperature, 3-bromopicolinamide is added and the mixture is kept about 75°C. for three hours, then worked up by cooling, diluting with ice water, filtering off the resulting solid, washing it with water, drying and recrystallizing from aqueous dimethylformamide to give 3-(p-methoxybenzylthio)picolinamide, m.p. 252°C. (dec.).

1. waitthe mixture is kept about 75°C. for three hours
2. temperatureby cooling
3. filtrationfiltering off the resulting solid
4. washwashing it with water
5. customdrying
6. customrecrystallizing from aqueous dimethylformamide