Acetic Anhydride → 3-Bromopyridine-2-carbonitrile

HRID 1658321Notes

Reaction equation

HRID 1658321 reaction equation
[Br:1][C:2]1[C:3]([C:8]([NH2:10])=O)=[N:4][CH:5]=[CH:6][CH:7]=1.C(OC(=O)C)(=O)C>>[Br:1][C:2]1[C:3]([C:8]#[N:10])=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 215291573-Bromopicolinamide

Product 1

HCID 8176943-Bromopyridine-2-carbonitrile

Procedure

3-Bromopicolinamide, prepared as in Example 2(4 g.) is heated with 100 ml. of acetic anhydride on a steam bath. The mixture is then concentrated and worked up by diluting and triturating with water. The solid is dried and sublimed to give 3-bromopicolinonitrile.

Workup

  1. temperatureis heated with 100 ml
  2. concentrationThe mixture is then concentrated
  3. additionby diluting
  4. customtriturating with water
  5. customThe solid is dried

Sources & evidence

ORD record
ord-9e679648ec20451fb4ef3e09cf16088a
Source dataset
uspto-grants-1976_06
Patent number
US03963733

Reaction notes

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