Acetic Anhydride → 3-Bromopyridine-2-carbonitrile

Participants

Reaction Steps

3-Bromopicolinamide, prepared as in Example 2(4 g.) is heated with 100 ml. of acetic anhydride on a steam bath. The mixture is then concentrated and worked up by diluting and triturating with water. The solid is dried and sublimed to give 3-bromopicolinonitrile.

Provenance & Evidence