Ethanol → Ethyl 3-chloropyridine-2-carboxylate

HRID 1658322Notes

Reaction equation

[Cl:1][C:2]1[C:3]([C:8]([OH:10])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.B(F)(F)F.[CH2:15](O)[CH3:16]>>[Cl:1][C:2]1[C:3]([C:8]([O:10][CH2:15][CH3:16])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 3

HCID 702Ethanol

HCID 6356Boron trifluoride

HCID 8246323-Chloropyridine-2-carboxylic acid

Product 1

HCID 15414991Ethyl 3-chloropyridine-2-carboxylate

Procedure

3-Chloropicolinic acid is esterified using boron trifluoride and ethanol by the procedure described in Example 1 to give ethyl 3-chloropicolinate.

Sources & evidence

ORD record: ord-c05d31b8ac324984bb1337a220e7d723
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03963733

Reaction notes

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