Dichloromethane → 1-(4-Chloro-o-tolyl)piperazine

HRID 165834Notes

Reaction equation

HRID 165834 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([CH3:21])[cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:29][CH2:30][Cl:31].[OH:22][C:23]([C:24]([F:25])([F:26])[F:27])=[O:28]>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([CH3:21])[cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66757902Tert-butyl 4-(4-chloro-2-methylphenyl)piperazine-1-carboxylate

Product 1

HCID 1008521-(4-Chloro-o-tolyl)piperazine

Sources & evidence

ORD record
ord-db8edd12259145ff8a1d00a46bd7afa8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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