HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1658343Generated: November 1, 2026
Ethyl Bromide → Ethyl 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
https://huagongshe.com/reaction/1658343
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Bromide | HCID 6332 | — |
| Reactant | HCID 21529188 | HCID 21529188 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate | HCID 118457 | 80% |
Reaction Steps
A mixture containing 1 g of ethyl 4-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate, 1.26 g of ethyl bromide and 20 ml of toluene was heated in a sealed tube at 130°C for 7 hours. The solvent was evaporated and the residue was worked up as above. There was obtained 0.8 g of ethyl-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03963736 |
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| Source dataset | uspto-grants-1976_06 |
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| ORD ID | ord-9fbd17d025d04905bf2dc1f05a5ea4f7 |
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| Source note | uspto-grants-1976_06 |
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