Ethyl Bromide → Ethyl 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
Reaction equation
C([O:3][C:4]1[C:13]2[C:8](=[N:9][C:10]([CH3:14])=[CH:11][CH:12]=2)[N:7]=[CH:6][C:5]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16])C.[CH2:20](Br)[CH3:21]>C1(C)C=CC=CC=1>[CH2:18]([O:17][C:15]([C:5]1[C:4](=[O:3])[C:13]2[C:8](=[N:9][C:10]([CH3:14])=[CH:11][CH:12]=2)[N:7]([CH2:20][CH3:21])[CH:6]=1)=[O:16])[CH3:19]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 130 °C
Procedure
A mixture containing 1 g of ethyl 4-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate, 1.26 g of ethyl bromide and 20 ml of toluene was heated in a sealed tube at 130°C for 7 hours. The solvent was evaporated and the residue was worked up as above. There was obtained 0.8 g of ethyl-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate.
Workup
- customThe solvent was evaporated
Sources & evidence
- ORD record
- ord-9fbd17d025d04905bf2dc1f05a5ea4f7
- Source dataset
- uspto-grants-1976_06
- Patent number
- US03963736
Reaction notes
Loading…