Morpholine → HCID 53892317, compound

HRID 1658371Notes

Reaction equation

HRID 1658371 reaction equation
[C:1]1([C:7]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>C1C=CC=CC=1>[F:16][C:13]1[CH:14]=[CH:15][C:10]([CH:9]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 2363292-(4-fluorophenyl)-1-phenylethanone

Product 1

HCID 53892317HCID 53892317, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 4-fluorobenzyl phenyl ketone (50g), morpholine (45g) and benzene (100ml) was refluxed overnight with molecular sieve, type 4A, to afford 2-(4-fluorophenyl)- 1-phenyl-1-morpholinoethylene. The latter compound (0.2 mole), cyanoacetamide (0.2 mole), diethylamine (2ml), sulphur (0.2 mole) and ethanol (100 ml) were stirred overnight at room temperature and then added to water. The crude product was recrystallised from ethanol and then from nitromethane to give pure 2-amino-5-(4-fluorophenyl)- 4-phenyl-3-thiophene carboxamide, m.p. 205°-7°.

Sources & evidence

ORD record
ord-551c1fd704cf4ffe86bab08934c3a9de
Source dataset
uspto-grants-1976_06
Patent number
US03963750

Reaction notes

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