Morpholine → HCID 53892317, compound

Participants

Reaction Steps

A mixture of 4-fluorobenzyl phenyl ketone (50g), morpholine (45g) and benzene (100ml) was refluxed overnight with molecular sieve, type 4A, to afford 2-(4-fluorophenyl)- 1-phenyl-1-morpholinoethylene. The latter compound (0.2 mole), cyanoacetamide (0.2 mole), diethylamine (2ml), sulphur (0.2 mole) and ethanol (100 ml) were stirred overnight at room temperature and then added to water. The crude product was recrystallised from ethanol and then from nitromethane to give pure 2-amino-5-(4-fluorophenyl)- 4-phenyl-3-thiophene carboxamide, m.p. 205°-7°.

Provenance & Evidence